We’ve officially hit double digits in the 2026 NFL regular season, and the action is red-hot on the gridiron as Week 10 is set to deliver some can’t-miss clashes. The only way this football Sunday could get any better is by scoring a juicy payday with our best NFL Week 10 underdog picks against the spread.
Below, we’ve featured our top expert picks from the latest NFL odds, highlighting three viable underdogs to pull off the upset in Week 10. Along with each pick, we’ve provided in-depth insight so you can get a thorough understanding of why these are your best bets for the weekend.
Don’t wait, head to your favourite NFL betting site, load up your bet slips, and get ready to stand shoulder-to-shoulder with other legendary underdogs like Rudy, Michael Oher, and more with our NFL Week 10 underdog picks.
- Carolina Panthers +1.5
- Miami Dolphins +2.5
- Cleveland Browns +4.5
Panthers +1.5
At 3-5, most teams would be looking ahead toward the draft in a down year, but thankfully, if you’re in the NFC South, that’s good enough to be a division leader. This is the current situation for the Carolina Panthers as they aim to remain atop the division as they enter a hostile environment, taking on a heated rival in the New Orleans Saints.
With the winner of this matchup set to place themselves atop the division standings, bank on the Panthers to pull off the upset as slight underdogs, covering the spread, and securing a victory on the road against a weak Saints team.
Coming off a loss that saw them take an L against a tough Denver Broncos squad after leading heading into the fourth quarter, the Panthers aren’t contenders, but they’re certainly no pushover. Having matched up well with top NFC teams, including a victory against the Detroit Lions, the Panthers have managed to play up to the level of their opposition and continue fighting until the final whistle.
Across the field from them, the same can be said of the Saints, but the major difference lies in their ability to finish in high-pressure situations. After narrowly escaping a win against a shorthanded Cleveland Browns team in Week 9, the Saints have finished three straight weeks with a game decided by a single score. With their inability to pull away on the scoreboard due to hot-and-cold play, and with a home-field playoff game on the line, the Saints may once again crumble under pressure.
Additionally, the Saints have struggled to cover the spread as favourites in 2026, sporting a 1-3 record against the spread (ATS), as well as having gone 0-4 ATS at home.
Set for a closely contested affair, bank on the Panthers to jockey for the lead, remain composed, and silence the crowd at the Caesars Superdome as they pull off the upset in Week 10.
Dolphins +2.5
Entering the 2026 season, expectations were low for the Miami Dolphins, and while they definitely haven’t “defied” pundits’ expectations, they have played far better than advertised. Having secured a win, a divisional victory to boot, look for the Dolphins to take advantage of a team in the midst of a self-destruct sequence as they cover the spread against the Indianapolis Colts.
Having already traded away franchise cornerstones such as offensive lineman Quenton Nelson and defensive tackle DeForest Buckner, the Colts’ fire sale is far from over, with key offensive players like Jonathan Taylor and Josh Downs actively being shopped ahead of the 2026 Trade Deadline as of this writing. Even if some of these top stars aren’t moved, morale has never been lower, and frustrations are beginning to reach a boiling point.
Without motivation to win and with pride set aside, this opens the door for a pesky Dolphins team to swoop in and capitalize on the Colts’ implosion. Having dropped three of their last four losses to teams with winning records by just a single score, as they set their sights on a squad in equally dire straits, bank on the Dolphins to capsize the Colts and cover the spread as road underdogs in Week 10.
Browns +4.5
Rounding out our best underdog picks for Week 10, expect a closely-contested showdown between AFC squads looking to make an aggressive playoff push as the Cleveland Browns cover the spread against the Houston Texans.
Coming off a dominant showing in Week 10, the Texans looked like they were finally clicking on all cylinders. Alas, that’s just what playing the Los Angeles Chargers makes mediocre teams look like. Nothing has changed within the Texans that makes them any more dangerous than their 3-5 record indicates. Having been handed losses to subpar teams such as the Colts and the New York Giants, the Texans won’t find the same success this Sunday against the Browns.
Without Deshaun Watson under centre, the Browns nearly escaped with a road win over the Saints in overtime, with the game coming down to a failed two-point conversion. Continuing to defy the odds, they sport a winning record and are primed to regain a postseason spot with a win this weekend.
Not only have the Browns been solid when it comes to wins and losses, but they’ve also been one of the best teams in the NFL against the spread. With a 6-3 ATS record, 5-3 as underdogs, and 3-0 at home, the Browns have had no trouble proving the oddsmakers wrong this season, putting forth valiant efforts and staying within striking distance week to week.
On the other side of the equation, the Texans have been inept when it comes to covering when favoured, sporting a 2-4 ATS record.
Hungry, motivated, and capable, bank on the Brownies to stay in the fight all game long, covering the spread, and earning you a hefty payday as an underdog in Week 10.
