2026 NFL Draft Odds: Fernando Mendoza Favourite to go Number 1

Written by: Matthew Eichhorn Fact checked by: Jaclyn Hurst

Last Updated: March 24, 2026

Indiana quarterback Fernando Mendoza (-20000) currently leads the latest 2026 NFL Draft odds to be named the first overall pick. Check out all the latest NFL odds on the Draft below and see how you can win big while betting on the latest crop of talent to enter the NFL.

2026 NFL Draft Betting Odds: First Overall Pick 1️⃣

The 1st overall NFL draft odds below are courtesy of bet365 and were last updated on Mar 25, 2026:

Matt’s NFL Draft Prediction 

For anyone looking to place an NFL draft prediction on the first overall pick, Fernando Mendoza is the bet to make. Mendoza is as close to a sure thing as you can get, holding incredibly long odds to be named the first overall selection by the Las Vegas Raiders.

Coming off a Heisman-winning campaign, Mendoza capped it off by capturing a National Championship in one of the best single-seasons of any NCAA player in history. With elite talent, incredible upside, and a history of success, Mendoza is the no-brainer first overall pick in this year’s draft.

👉 My Pick: Fernando Mendoza (-20000)

Fernando Mendoza to go 1st overall

-20000

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2026 NFL Draft Odds: Second Overall Pick 2️⃣

The 2nd overall NFL draft odds below are courtesy of bet365 and were last updated on Mar 25, 2026:

Matt’s NFL Draft Prediction

Still riding with the chalk on the latest NFL Draft betting odds, look for the New York Jets to select linebacker Arvell Reese out of Ohio State with the second overall pick. As a freak athlete that possesses both elite size and football IQ, Reese will be a fantastic addition to a Jets defence that was pummeled all last year.

👉 My Pick: Arvell Reese (-190)

Arvell Reese to go 2nd overall

-240

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2026 NFL Draft Odds: Third Overall Pick 3️⃣

The 3rd overall NFL draft odds below are courtesy of bet365 and were last updated on Mar 25, 2026:

Matt’s NFL Draft Prediction

My NFL Draft prediction for the third overall pick by the Arizona Cardinals is tackle Francis Mauigo out of Miami. The big-bodied lineman was sensational for the Hurricanes this season, using all of his six-foot-five, 330lbs frame to protect the quarterback and generate stellar blocks on the edge. With the Cardinals desperately in need of assistance on the line, Mauigoa is a natural fit.

👉 My Pick: Francis Mauigoa (+350)

Francis Mauigoa to go 3rd overall

+250

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Previous 1st Overall NFL Draft Picks ⏱️

Best NFL Betting Sites in Canada 🍁

How To Bet On the NFL Draft in Canada 🍁

New to betting on the NFL Draft? Then be sure to check out our helpful step-by-step guide below that’ll have you ready to place your bets in no time. This is how to bet on the NFL Draft in Canada in four easy steps:

1. Choose a Sportsbook.
   Check out our recommended NFL betting sites above or our in-depth online sportsbook reviews to find the oddsmaker that’s right for you. Be sure to research the available betting markets, banking options, and the response time of their customer support team.
2. Create an Account.
   Sign up using the link provided to create an account. You’ll need to provide personal information such as your legal name, address, and birthdate to verify your identity and eligibility to bet on sports in your region.
3. Make a Deposit.
   Load up your new betting account with playable funds. Navigate to the banking centre of your sportsbook and find the deposit method that works best for you. Follow the outlined steps carefully to transfer funds into your account.
4. Place your Bets.
   Navigate to the NFL or football section of your sportsbook, select NFL Draft odds, select futures, choose your wager and confirm your bet slip. That’s it!

Tips for Betting on NFL Draft Odds 💡

To help you get the most out of your NFL Draft betting experience, we’ve provided some helpful tips & tricks below that’ll have you in a winning position for all your upcoming bets.

🤓 Research NFL Draft History

A great way to prepare your bets for the NFL Draft is to research recent NFL Draft history. Find trends like:

• Which positions are most often taken in the first round
• Schools that produce the most top picks
• Recent draft picks from each team (scroll up for that info!)

For example, the first overall pick has been a quarterback in eight of the last 10 drafts, including edge-rushers, and these two positions comprise the number one overall pick in the draft for the last decade.

🛒 Compare NFL Draft Odds

Maximize your winning potential by placing bets with the online sportsbook that offers you the best odds on your desired wager. Each betting site will provide its own unique odds value for each market, so by opening multiple sportsbook accounts, you can get the best bang for your buck by betting with the oddsmakers sporting the top value picks.

📉 Follow Trade Buzz

One factor that can shake up the NFL Draft and its odds is trades. With trades happening both pre-draft and during the draft, a draftee’s selection can fluctuate based on which team is on the clock.

Research the latest trade rumours for the NFL Draft, such as teams looking to move up or down in the draft order, and place your bets knowing that there’s a possibility that a pick will be moved.

The Most Popular NFL Draft Bets 💰

Check out the most popular NFL Draft bets on the market below to help you win big on all your upcoming wagers.

🏈 Number One Overall Pick

Wagering on the 2026 NFL Draft first pick odds is as simple as it gets, and the fastest-settling bet of the event. In this betting market, all you have to do is correctly pick who will be drafted first overall.

🏈 Over/Under Betting

Over/Under betting on the NFL Draft is when you bet on the draft position a player is selected at.

For example, if Ohio State linebacker Arvell Reese has an Over/Under draft position of 2.5, an Over bet would mean he’d need to be drafted third or later, and an Under bet would hit if he’s drafted first or second overall.

🏈 Position Draft Specials

Another great way to place wagers on your NFL Draft predictions is by betting positionally. In these betting markets, you can wager on markets such as the first offensive lineman drafted, the number of total specified positions to be drafted in the first round, and more.

For example, if you think that Texas Tech EDGE David Bailey will be coming off the board early in this year’s draft, you could place a bet on him to be the first defensive lineman to be selected in the draft.

🏈 Head-to-Head Draft Betting

The Draft isn’t a competition, but you can make it one by betting on which player will be drafted first between two upcoming prospects.

For example, between the top two wide receivers in the draft, you could bet on who will be drafted first between Makai Lemon and Carnell Tate head-to-head.

🏈 Live Betting

Every pick made in the Draft will send shockwaves throughout the NFL, including how other teams will draft later on. That’s why live betting on the NFL Draft can be a great way to wager on the action.

By seeing who’s coming off the board in real-time, you can use this to make educated guesses as to how other teams will draft after top talents are snagged in the selection process.

How to Read NFL Draft Odds 👓

For NFL Draft bets, you’ll need to know how to read odds to place your bets effectively. In these betting markets, a favourite is shown using a minus symbol (-) and an underdog with a plus symbol (+).

The minus sign indicates the amount that must be wagered to profit $100, while a plus sign shows the profit made by wagering $100.

For example, if in the 2025 NFL Draft Cam Ward was -200 to be drafted first overall, you’d need to wager $200 to win $100 if your pick is correct. Conversely, if you wanted to bet on a long shot like Will Campbell to be the first overall pick at +1000, a $100 wager would net you a $1,000 profit.

How the NFL Draft Works 📝

The NFL Draft is a simple concept that allows all 32 franchises to usher in fresh talent into the league. There are seven rounds in the NFL Draft, with a potential total of 224 players drafted into the league.

The draft order is determined by the previous season’s win-loss records, with the team that finished last drafting first, and the reigning Super Bowl Champions drafting 32nd. This order can change, however, as teams can trade draft picks throughout the year.

More NFL Betting Resources

• Best NFL Betting Sites in Canada
• NFL Teams
• Latest NFL News