Red Sox vs. Yankees Game 2 Predictions, Picks, And Odds

New York Yankees designated hitter Ben Rice (22) runs after hitting a grand slam home run against the Boston Red Sox during the eighth inning during game one of the Wildcard round for the 2026 MLB Playoffs at Yankee Stadium. Mandatory Credit: Brad Penner-Imagn Images

The Yankees moneyline at (-140) with bet365 is our prediction for Wednesday’s Wild Card Game 2. New York went 93-68 in the regular season and beat Boston 9-0 in Tuesday’s series opener, but Sonny Gray gives the Red Sox a much tougher counter on the mound than that score suggests.

Red Sox vs. Yankees Prediction

Yankees moneyline: (-140) at bet365

New York’s 46-34 record at Yankee Stadium adds to the case for backing the home side. The Yankees also had 12 hits to Boston’s three in Game 1.

Gray posted a 2.72 ERA in the regular season and a 1.98 ERA in two starts against New York. Boston went 46-35 on the road, too. Those are real reasons to keep this a moneyline lean at the quoted price, not a claim that the Yankees are a lock.

Yankees moneyline

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-140

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Red Sox vs. Yankees Odds

MarketPregame odds
Red Sox moneyline(+120)
Yankees moneyline(-140)
Run lineRed Sox +1.5 (-190), Yankees -1.5 (+160)
Game totalOver 6.5 runs: (-120), Under 6.5 runs (+100)
Date/timeWednesday, Sept. 30, 2026, 8 p.m. ET
VenueYankee Stadium, Bronx

Pregame odds courtesy of bet365.

Betting the Red Sox

Boston finished 87-75 and was better than its Game 1 showing suggests on the road, going 46-35 away from home. Still, three hits in a shutout loss make the offence the immediate concern for anyone taking the underdog at +120.

The Red Sox had a 3.54 staff ERA and a 3.00 bullpen ERA in the 2026 regular season. Aroldis Chapman, Garrett Whitlock and Garrett Crochet did not pitch in Game 1. Their Game 2 roles remain to be seen.

Betting the Yankees

Ben Rice went 4-for-5 with two home runs and six RBIs; that kind of production helped cover for Aaron Judge’s absence, but it’s not a sensible baseline for Game 2.

The Yankees’ regular-season staff ERA was 3.24, and closer David Bednar was not needed late in the opener.

Probable starting pitchers

Red Sox: RHP Sonny Gray (2.72 ERA, 1.15 WHIP, 149 strikeouts in 169 innings)

Gray is Boston’s confirmed Game 2 starter. He threw six scoreless innings against Cleveland on Sept. 23.

Yankees: LHP Max Fried (2.80 ERA, 0.99 WHIP, 104 strikeouts in 112⅔ innings)

Fried is confirmed for New York. He held Boston scoreless over eight innings with nine strikeouts on April 22, making this a matchup with quality starters on both sides. Fried threw 63 pitches against Boston on Aug. 29 in his first start back from a left elbow bone bruise; that earlier workload is not a stated limit for Wednesday.

Notable injuries and projected lineups

Roman Anthony left Game 1 in the sixth inning with right hand and wrist discomfort, and his Game 2 availability was uncertain afterward. Manager Chad Tracy said Anthony “took a check-swing and then another swing, and his hand flared on him, and it got uncomfortable, so we had to make a move there.” A right-wrist sprain in May had limited Anthony to 55 regular-season games.

Boston is also without Triston Casas (knee), Kutter Crawford (wrist) and Tanner Houck (arm). Willson Contreras played in Game 1 after missing eight of the Red Sox’s final nine regular-season games following a pitch to his hand.

Aaron Judge is off New York’s Wild Card roster while rehabbing a calf strain. Clarke Schmidt is out with an elbow injury.

Weather

Conditions listed for Yankee Stadium are cloudy and around 20 C, with wind near 5 mph and no precipitation. That alone isn’t a reason to play either side of the 6.5-run total.

  • New York went 46-34 at home in the regular season; Boston went 46-35 on the road.
  • Entering Game 2, the Yankees had won four of their past five games, while the Red Sox had won two of five. Both stretches include the postseason opener.
  • The teams split an Aug. 29 doubleheader at Yankee Stadium: New York won 9-2, and Boston won 6-0.
  • Rice had 151 regular-season hits and added four in Game 1. Over 0.5 hits is (-210) at bet365, a short price even after Tuesday’s four-hit night.
  • Fried’s strikeout line is 5.5 at bet365: Over (-105), Under (-130). His projection of 5.68 strikeouts sits close to that number.
  • Gray’s 5.5 strikeout line is priced at (-115) on either side at bet365. His projection of 5.15 strikeouts doesn’t make either side an obvious second pick.