The oddsmakers always think they know best, but this weekend, let’s show that they don’t know Jack and win big on the top mispriced odds with our NFL Week 5 Over/Under picks. Below, we’ve highlighted our expert picks and predictions on the NFL games that we see far exceeding the line set by oddsmakers, setting you up for a hefty payday on this Sunday’s action.
Don’t wait, check out the latest NFL odds at your favourite NFL betting site, load up your bet slip, and boost your bankroll with our Week 5 Over/Under picks.
- PHI Eagles vs. JAX Jaguars Over 43.5 Points (-105)
- DET Lions vs. ARI Cardinals Over 53.5 Points (-115)
- SF 49ers vs. SEA Seahawks Over 47.5 Points (-105)
Eagles vs. Jaguars Over 43.5 Points (-105)
Kicking things off with a point total pick that’s nearing plus money with one of the lowest Over/Under lines set, hammer the Over in the Philadelphia Eagles vs. Jacksonville Jaguars in Week 5.
While there’s been plenty of discourse surrounding the effectiveness of the Eagles offence, one thing that can’t be argued is their ability to hit Overs. Through the first quarter of the 2026 NFL season, the Eagles sport a 75% Over rate, putting them in the NFL’s top 10 in this regard. Even shorthanded, the Eagles embrace the next-man-up mentality and haven’t seen their production diminish, even without top playmakers like Saquon Barkley and DeVonta Smith.
Taking on a high-powered offensive squad in the Jaguars, who are capable of lighting up a scoreboard in an instant, expect these two teams to rattle off multiple scoring drives, finding the end zone routinely, and hitting the Over early on in their Week 5 clash.
Lions vs. Cardinals Over 53.5 Points (-115)
Expect plenty of fireworks on the gridiron in this Week 5 showdown as the Detroit Lions and Arizona Cardinals go shot-for-shot in a high-scoring shootout that results in Over 53.5 points.
Hot off the heels of a Sunday Night Football thriller against the Carolina Panthers, the Lions once again found themselves in the middle of a firefight. Through their first four games of the season, the Lions have finished each contest with Over 53.5 total points scored in the game. With their elite offence continuing to fire on all cylinders, coupled with their inept defence, the Lions have become the perfect team to bet the Over on in 2026.
Taking on a Cardinals squad that’s no stranger to high-scoring affairs in their own right, having finished back-to-back games with Over 53.5 total points scored in the matchup, you can bank on both of these teams to find the back of the end zone on almost every drive throughout the game.
In what’s sure to be one of the most fun games to watch of Week 5, look for the Lions and Cardinals to send the scoreboard skyrocketing as they quickly combine for Over 53.5 total points in their upcoming clash.
49ers vs. Seahawks Over 47.5 Points (-105)
In a pivotal battle for the top spot in the NFC West on the line, expect both sides to leave it all out on the field, resulting in a high-scoring showdown as the San Francisco 49ers take on the Seattle Seahawks this Sunday.
Beginning to show cracks in their sensational defence, the defending Super Bowl champion Seahawks have struggled to get stops as of late. Having allowed 56 total points over their last two games, they’ve also hit the Over mark on 47.5 points in each contest.
Facing a 49ers team that’s consistently strung together high-volume scoring performances, the Seahawks are set to struggle to contain an offence that’s scored at least 24 points in all four matchups so far in 2026.
As the 49ers look to remain unbeaten and in control of the division, the Seahawks are sure to bring their A-game as they look to put on a show for their home crowd, securing a win in a high-scoring, back-and-forth duel that totals Over 47.5 points.
