Heading into Week 4 of the 2026 NFL season, the board is wide open this week as we’ve got a smorgasbord of terrific matchups with juicy odds waiting for us to sink our teeth into. That’s why we’ve highlighted our best NFL Week 4 underdog picks against the spread so you can upset the oddsmakers and boost your bankroll as you defy the odds on your upcoming football bets.
Head to your favourite NFL betting sites, check out the latest NFL odds, and load your Week 4 bet slip with our best bets and win big on all the upcoming action with these underdog picks against the spread.
- Jacksonville Jaguars +2.5 (-108)
- Dallas Cowboys +2.5 (-110)
- Denver Broncos +3 (-110)
Jacksonville Jaguars +2.5 (-108)
Set for a high-octane matchup you won’t want to take your eyes off of, expect fireworks on the gridiron in Week 4 as the Jacksonville Jaguars enter into a hostile environment as they take on the Cincinnati Bengals. In a clash between two of the league’s top-scoring offences, bank on the Jaguars to have the superior firepower in a high-scoring shootout, covering the single-score spread as underdogs.
Coming off a 35-6 shellacking of the New England Patriots in Week 3, the Jags have looked like a well-oiled machine in 2026. With explosive production on the offensive side of the ball, coupled with a stupendous defensive unit, the Jaguars are quickly establishing themselves as a team to watch in the AFC.
Set to take on a Bengals team that allowed 30 points to a shaky Steelers squad, look for the Jaguars to have no trouble producing offensively, lighting up the scoreboard, while limiting the opposing star power across from them from generating their usual production. At +2.5, this spread gives you just enough insurance in the event this game goes down to the wire, but you can feel confident in Trevor Lawrence and company to get the job done this weekend.
Jaguars +2.5
Dallas Cowboys +2.5 (-110)
Just like my time on spring break, it was heartbreak in Rio de Janeiro for the Dallas Cowboys as Tyler Loop knocked through a 56-yard game-winning field goal as time expired to take the win in for the Baltimore Ravens. Feeling rightfully aggrieved, look for the Cowboys to take out their frustration in a road clash against the Houston Texans in Week 4.
While their defence has maintained its elite play from a season ago, the Texans offence has been completely out of sorts. With quarterback C.J. Stroud unable to generate consistent offence, it’s been tough to watch the Texans move the ball downfield at times in 2026.
With their defence set for another long night at the office as they’re tasked with containing a high-powered Cowboys squad, their offence is sure to be put through the ringer as they struggle to generate yardage against a formidable Cowboys defence.
In a matchup I firmly believe the oddsmakers got wrong, back the Cowboys to win the battle for supremacy in the Lone Star State, covering the spread as underdogs, and netting you a Texas-sized payday in the process.
Cowboys +2.5
Denver Broncos +3 (-110)
Rounding out our best NFL Week 4 underdog picks against the spread, look no further than the red-hot Denver Broncos to pull off yet another upset, this time against the San Francisco 49ers.
Proving that they’ve still got the grit, heart, and determination that helped them finish with the best record in the AFC in 2025, the Broncos had a second half for the history books as they erased a 16-0 halftime deficit to come back and defeat the Los Angeles Rams at home. Now set to head to California this Sunday, look for Sean Payton and the Broncos to trample an injury-riddled 49ers club in Week 4.
Set to be without top wide receiver Mike Evans, as well as sporting a defence with more holes than a gopher-infested backyard, the 49ers simply can’t match the pace, depth, and upside of the Broncos.
Opening at a short +3 spread, bank on the Broncos to continue their winning ways, propelling themselves up the AFC standings, and continuing their quest back to the AFC Championship game as Bo Nix and co. look for redemption this season.
