Best NFL Player Prop Bets for Week 3

James Cook, 2026 NFL Season, Buffalo Bills

One of the most exciting ways to bet on NFL action is through player prop bets. Nothing beats getting some skin in the game on the performance of the game’s biggest stars, so we’ve compiled the best player prop bets for Week 3 in one place.

Below, we’ve broken down our expert picks and provided in-depth NFL odds analysis so you can gain a winning edge on all your wagers this weekend. Don’t wait; head to your favourite NFL betting site, lock in your picks, and get ready to score that touchdown-scoring feeling with our best NFL player prop bets for Week 3.

  • Amon-Ra St. Brown Over 80.5 Receiving Yards
  • James Cook Over 79.5. Rushing Yards
  • Christian McCaffrey Over 56.5 Rushing Yards

Amon-Ra St. Brown Over 80.5 Receiving Yards

One of the league’s top receiving talents, you can expect a big performance out of Detroit Lions superstar Amon-Ra St. Brown as he hauls in Over 80.5 receiving yards against the New York Jets.

While the Jets have done a solid job of limiting opposing passing attacks in their first two weeks of action, they haven’t faced a team with the offensive talent level of the Lions to this point. With St. Brown and the Lions no stranger to long drives downfield, he’s the unquestioned top option in their passing game.

Coming off a 142-yard performance against the Buffalo Bills on Thursday Night Football, St. Brown is set to continue putting up All-Pro numbers as he receives a healthy diet of targets from quarterback Jared Goff, quickly leading to him exceeding his receiving yards total this Sunday.

James Cook Over 79.5 Rushing Yards

An explosive backfield talent, Bills running back James Cook is primed for a big outing as he takes on a struggling Los Angeles Chargers squad. With defences always on their heels as they hone in on former MVP quarterback Josh Allen, Cook is oftentimes the forgotten man, making defences pay accordingly.

In his last appearance on the gridiron, Cook lived up to his surname as he racked up 135 rushing yards against the Lions, cooking the defence every time the ball touched his hands. Forming a dynamic rushing duo alongside his mobile QB, expect Cook to have no trouble putting up impressive numbers on the ground as he faces a Chargers defence that’s allowed 26 points in back-to-back games to open their 2026 campaign.

Looking to become the first running back to lead the league in rushing yards in consecutive seasons since Derrick Henry in 2019-2020, bank on Cook to rumble his way on the turf to Over 79.5 rushing yards against the Chargers.

Christian McCaffrey Over 56.5 Rushing Yards

Capping off our best NFL Week 3 player props, look no further than backing three-time All-Pro running back Christian McCaffrey to get the job done on the ground, finishing with Over 56.5 rushing yards in a divisional clash against the Arizona Cardinals.

While McCaffrey has struggled in the past to stay on the field, when he’s healthy, there’s no talent that can match his offensive output. After cruising his way to two touchdown scores in a blowout over the Miami Dolphins in Week 2, CMC is poised to see his rushing yardage increase this Sunday. Coming off a crushing defeat to the Seattle Seahawks, the Cardinals allowed 162 rushing yards in the loss, doubling the rushing yards allowed in their Week 1 upset over the Chargers.

With the Cardinals run defence clearly a weakness in their game plan, expect to see McCaffrey on the receiving end of a plethora of handoffs, juking defenders, and snapping ankles en route to the end zone as he finishes with Over 56.5 rushing yards in this NFC West showdown.