Looking to gain a winning edge over the oddsmakers in your football bets this weekend? Then you’ve come to the right place, as we’re here to take a deep dive into the best NFL Week 6 underdog picks against the spread.
Below, we’ve highlighted our top NFL Week 6 underdog picks against the spread, isolating the squads that we see having the best chance to cover the spread and maybe even pull off the upset victory outright.
Don’t wait, check out the latest NFL odds, follow our picks on the best NFL betting sites, and win big with our top Week 6 underdog picks against the spread.
- CAR Panthers +1.5
- ATL Falcons +3
- TB Buccaneers +3
Panthers +1.5
Kicking things off with a team that’s only a slight underdog, look for the Carolina Panthers to pounce on their wounded prey as they tear apart the Philadelphia Eagles this Sunday, picking up the upset victory in the process.
Coming off their Week 5 bye, the Panthers are well-rested and motivated to take advantage of an Eagles team that’s completely out of sorts. With lacklustre play across the gridiron and injuries to key contributors like Saquon Barkley and DeVonta Smith, the Eagles have struggled mightily to produce consistent, week-to-week production.
The Eagles inconsistencies are shown in their ATS record heading into Week 6, sporting a 1-4 record, ranking them as tied for the second-worst covering team in football. Meanwhile, the Panthers are 2-2 ATS but have shown a dynamic offence, hard-hitting defence, and strong mental toughness, qualities the Eagles have seldom displayed.
With injury designations still a question mark heading into Sunday, the Panthers are a safe bet to cover the spread as underdogs, and may even find themselves flipping the script come kickoff and entering the game as favourites. Until then, back the Panthers to pull out the upset and continue holding down the top spot in the NFC South.
Falcons +3
Still reeling from a heartbreaking overtime loss to a shorthanded Baltimore Ravens team on Sunday Night Football, bank on the Atlanta Falcons to get their season back on track as they cover the spread as underdogs against the Chicago Bears.
In a battle between teams with banged-up quarterback rooms, look for the supporting cast of the Falcons to simply be too explosive for the Bears to match. While the Bears possess terrific offensive upside when healthy, they’ve struggled to find their big-play ability with Tyson Bagent under centre. Inversely, the Falcons have still found ways to produce when quarterback Michael Penix has been out of the lineup thanks to an elite run-game led by dangerous running back talent Bijan Robinson.
With scoring drives potentially set to come at a premium in this one, look for the Falcons superior talent to create big plays downfield, setting up easy field goals or highlight-reel touchdowns as a result.
Buccaneers +3
Rounding out our trio of NFC South teams to cover the spread in Week 6, back the Tampa Bay Buccaneers to build off their momentum garnered from their Thursday Night Football upset win over the Dallas Cowboys, covering the spread against the Pittsburgh Steelers.
In what’s sure to be a hard-hitting, defensive collision course, the Buccaneers defence is set to be the difference-maker in this showdown. While the Steelers’ identity has long been attached to their tough-as-nails defence, they simply aren’t the same beast in 2026.
Having allowed 21+ points in three-straight weeks, the Steel City has had to rely on a some throwback showings from living legend Aaron Rodgers to keep themselves in games. At 41, this isn’t something you can continue to rely on, especially when facing a defence that currently ranks fourth in the NFL in EPA allowed per play.
Look for the Buccaneers defence to swarm Rodgers and the Steelers offensive line, forcing turnovers, and limiting big plays downfield, while undrafted rookie Jaylon Daniels continues to break out for the Buccaneers, leading them to an upset win at home.
