We’re capping off Week 16 with a pivotal battle between NFL interconference foes that are both jockeying to gain control of their respective divisions. In what’s set to be a thrilling primetime affair, the San Francisco 49ers will look to extend their three-game winning streak against Phillip Rivers and the Indianapolis Colts.
In a duel that will have major ramifications in both the AFC and NFC playoff races, why not raise the stakes of this Monday Night Football showdown by placing a 49ers vs. Colts same game parlay?
Below we’ve provided expert insight & analysis, as well as the best bets available on this upcoming tilt. Don’t wait, cash in just before the holidays and stuff your stocking full of cash with our 49ers vs. Colts same game parlay.
- Colts +5.5 (+100)
- Alec Pierce 20+ Receiving Yards (-110)
- Christian McCaffrey Anytime Touchdown Scorer (-225)
Matt’s 49ers vs. Colts Same Game Parlay
Colts +5.5 (+100)
After making the controversial decision to sign literal grandfather Phillip Rivers off the street and into pads in Week 15, the Colts managed to prove some naysayers wrong last week as they went down to the wire against the top team in the NFC, the Seattle Seahawks. With the Colts appearing to still have some gas in the tank for a last-ditch effort to make the 2025 NFL playoffs, expect them to once again hang tough at home as they cover the spread as underdogs against the 49ers.
Still rostering explosive offensive talents such as tight end Tyler Warren and the NFL leader in touchdowns, Jonathan Taylor, the Colts aren’t shy of upside heading into Monday Night Football. While the Niners have managed to once again exceed expectations this season, their defence has been weak, opening the window for a solid scoring performance from the Colts, while their hard-nosed defence offers trouble to the 49ers’ star-studded offence.
Expect a competitive tilt on primetime as the Colts remain competitive, pushing for the upset victory, and covering the 5.5-point spread in the process to help notch you a winning same game parlay.
Alec Pierce 20+ Receiving Yards (-110)
The top deep-ball threat on the Colts, look for wide receiver Alec Pierce to snag 20+ receiving yards early on in this contest. While targets came at a premium for the fourth-year receiver in his first taste of action, playing alongside Rivers, you can still trust him to turn coal into diamonds in limited receptions.
In just his lone reception in Week 15 against the Seahawks, Pierce racked up 16 yards. With big-play potential in spades, even if Rivers doesn’t have the arm to connect with Pierce for a long bomb downfield, he can still use his superb size and athleticism to make big plays on long-distance downs.
Having recorded a 20+ yard reception in 10 of his 12 games played this season, bank on Pierce to have no trouble producing a big play for his team against a weak Niners defence, notching you a profitable boost to your Colts vs. 49ers same game parlay.
Christian McCaffrey Anytime Touchdown Scorer (-225)
Continuing to build upon what has been a Hall-of-Fame career, 49ers running back Christian McCaffrey is a smart bet to find his way into the end zone against the Colts. Sitting four touchdowns behind Taylor for the lead in the NFL, CMC will be hungry to make the most of the final games of the regular season as he punches his way in for a score on Monday Night Football.
Having scored in four straight games, as well as five of his last six, McCaffrey is a dangerous dual-threat back that can torch defences both on the ground and through the passing attack. With his versatile skillset and elite agility, CMC is borderline unstoppable in the open field.
While he may not offer a ton of juice to your 49ers vs. Colts same game parlay, he is a safe pick that will help you land an eventual payout, without sacrificing too much in the way of value. Bank on McCaffrey to extend his scoring streak and hit paydirt on Monday Night Football.