As we begin to wrap up what was a thrilling week of NFL action, we’ve got a clash between two NFC hopefuls on primetime this evening as the Carolina Panthers take on the San Francisco 49ers on Monday Night Football Week 12.
With both teams looking to make an aggressive playoff push as we approach the tail end of the 2025 NFL season, the stage is set for a high-stakes matchup on Monday Night Football. The only way the action could get any better is by placing a bet using our Panthers vs. 49ers same game parlay.
Below, we’ve crafted a juicy three-leg same game parlay on Monday Night Football that’ll have your bankroll booming as we cap off Week 12 of the NFL season. Don’t wait, check out my expert picks below, as well as in-depth betting analysis for each featured pick, and earn your next primetime payday with our Panthers vs. 49ers same game parlay.
- 49ers -3.5 (-198)
- Bryce Young Over 1.5 Passing Touchdowns (+135)
- George Kittle Anytime Touchdown Scorer (+140)
Matt’s Panthers vs. 49ers Same Game Parlay
49ers -3.5 (-198)
Set for a dominant showing at home over a hot-and-cold Panthers team, bank on the 49ers to cover a -3.5-point spread on Monday Night Football. For this pick, we’re teasing the line down from the set -7.5-point spread, sacrificing some value in order to gain some insurance on the final score of this matchup.
While both sides sport potent offences that are sure to light up the scoreboard, the upside of the 49ers is too good to compete with. Rostering All-Pro talents like George Kittle and Christian McCaffrey on offence, as well as a well-coached defence in the system of Kyle Shanahan, the Panthers are going to be a step behind the 49ers all night.
In a tilt that’s likely going to be determined by whose offence can outscore the other, look for the talent of the 49ers to shine bright, sending the Panthers back into the loss column, and remaining competitive within the uber-tough NFC West as they hope to stay within the Wild Card spot of the 2025 NFL Playoffs.
Bryce Young Over 1.5 Passing Touchdowns (+135)
Beginning to finally find his footing as an NFL quarterback, look for Panthers QB Bryce Young to throw Over 1.5 passing touchdowns on Monday Night Football. Coming off of an impressive outing against the Atlanta Falcons in which he threw for three touchdowns, look for this trend to continue against the 49ers.
While they may be one of the most well-oiled machines in the NFL, the 49ers’ defence is porous. With a depleted roster due to offseason moves and constant injuries, the Niners’ defence has been taken advantage of throughout their current campaign. Notably, the 49ers have allowed opposing quarterbacks to complete 2+ passing touchdowns in four-straight games played.
With no lockdown members in the secondary, look for Young to have no trouble letting the pig skin fly as he connects downfield for big gains throughout the contest, using his stellar arm to put points on the board.
At plus money, look for Young to continue building his presence as a rising star in the league, tossing Over 1.5 passing touchdowns against the 49ers, and earning you an easy win on your Monday Night Football picks.
George Kittle Anytime Touchdown Scorer (+140)
Set to add plenty of juice and excitement to your Panthers vs. 49ers same game parlay, look for the eccentric Niners’ tight end George Kittle to play his way into the end zone as he hits paydirt on Monday Night Football.
Having scored a touchdown in back-to-back games, Kittle has been a go-to end zone threat for the 49ers. With touchdowns scored in four of his six games played this season, there’s no arguing the dependability of Kittle as a touchdown scorer for his team. Dominating the target share for the 49ers in the red zone, once they get close to the goal line, you can expect plenty of attention to go toward Kittle.
At +140, there’s amazing value in this pick, helping make for a solid return on your same game parlay, and allowing you to get that touchdown feeling alongside the star tight end with this moneymaking player prop bet.