The 2025 NFL season has been a thrilling, unpredictable, and exciting rollercoaster that has led us to a big game in Week 6 in the NFC East as the Philadelphia Eagles take on the New York Giants.
Below, I’ve featured my expert picks & predictions ahead of kickoff on Thursday Night Football Week 6, as well as some of the top moneymaking betting trends and player prop bets for this rivalry matchup.
For Thursday Night Football Week 6, my best bet is to take the Eagles to cover the spread against the Giants.
PHI Eagles spread -7.5
-105
Thursday Night Football Best Bet: Eagles to Dominate the Giants (-7.5)
In a battle between two teams coming off disappointing losses in Week 5, the Eagles are primed to take out their frustrations on the Giants in this primetime affair. While the Eagles were unable to defeat the Denver Broncos, this was still at the very least a respectable loss. The same cannot be said about the Giants’ defeat to the New Orleans Saints.
With the honeymoon phase worn off for Giants quarterback Jaxson Dart, look for him to continue his rookie season struggles against the defending Super Bowl champions.
Possessing a solid front seven on defence that features top talents such as Jalen Carter, Jordan Davis, and Zack Baun, look for the Eagles to make mincemeat of the Giants’ shoddy offensive line, terrorizing Dart in the backfield, and reducing the output of breakout rookie running back Cam Skattebo as they leave little to no openings to run through.
As they control the line of scrimmage on the defensive end, look for the Eagles to do the same offensively, employing their usual brand of smashmouth football led by star running back Saquon Barkley and quarterback Jalen Hurts. Additionally, the Giants have been one of the worst defences at stopping their opposition’s passing attack, which will lead to an increased output from the stud receiver duo A.J. Brown and DeVonta Smith on Thursday Night Football.
Bank on the Eagles to beat the Giants pillar-to-post on Thursday Night Football as they cover the 7.5-point spread as favourites to put themselves back firmly in control of the NFC East.
Eagles vs. Giants Betting Trends
- The Eagles have won seven of the past eight head-to-head meetings with the Giants. Of those seven victories, they won by eight or more points in five of them.
- Undefeated against the spread on the road this season, the Eagles have covered in both road matchups in 2025.
- The Giants enter Week 6 sporting an 80% hit rate on the under total points scored (4-1). This ties the Denver Broncos, Houston Texans, and Los Angeles Chargers for the highest under rate in the NFL this season.
- Winless in divisional play, the Giants are 0-2 against teams in the NFC East.
Player Props to Watch on Thursday Night Football
- TE Dallas Goedert Anytime Touchdown Scorer (+275) – Hit in three straight games.
- QB Jalen Hurts Over 1.5 Passing Touchdowns (+155) – Hit in three straight games.
- CB Paulson Adebo Over 5.5 Solo + Assist Tackles (-130) – Hit in four of five games played this season.
- DE Brian Burns to Record a Sack (+110) – Hit in four of five games played this season.
Thursday Night Football Injury Report
Eagles
- RB Saquon Barkley (Knee) – Questionable
- G Landon Dickerson (Ankle) – Questionable
- LB Jihaad Campbell (Biceps) – Questionable
- TE Grant Calcaterra (Oblique) Questionable
- DT Byron Young (Triceps) Questionable
- LB Nakobe Dean (Knee) – OUT
Giants
- QB Jaxson Dart (Hamstring) – Questionable
- RB Tyrone Tracy (Shoulder) – Questionable
- S Jevon Holland (Calf) – Questionable
- WR Darius Slayton (Hamstring) – Questionable
- LB Swayze Bozeman (Ankle) – Questionable
- S Dane Belton (Shoulder) – Questionable
- S Tyler Nubin (Groin) – Questionable
- CB Dru Phillips (Hip) – Questionable
- LB Demetrius Flanningan-Fowles (Hamstring) – Questionable
- T Jermaine Eluemunor (Back) – Questionable
- S Anthony Johnson Jr. – OUT