Capping off Week 5 of the 2025 NFL season with a great matchup between AFC contenders, the Kansas City Chiefs will travel south to Florida to take on the Jacksonville Jaguars at EverBank Stadium.
My best bet on Monday Night Football is the Chiefs moneyline against the Jaguars.
Chiefs Moneyline vs. Jaguars
-205
Monday Night Football Best Bet: Chiefs to Win Outright (-205)
Before I give my pick outright on the Chiefs, I must eat some crow first. Despite my offseason predictions on the future of this team, the Jaguars are actually a competent franchise through the early goings of the season.
That being said, the Chiefs are still the superior team in this matchup and are well-positioned to secure a road victory on Monday Night Football. With the return of wide receiver Xavier Worthy to the lineup, as well as some kinks seemingly being ironed out after dropping back-to-back contests to start the season, the Chiefs are beginning to roll into form.
Having made the Super Bowl in three straight seasons, you can never truly count out the Chiefs. In this clash with the Jags, look for the Chiefs to edge out the win by exposing their opponents’ subpar secondary, taking deep shots downfield repeatedly as they march toward the end zone. While the Jaguars may also find success thanks to their explosive offence, in a high-scoring shootout, they simply don’t have the firepower to compete with KC.
Expect a competitive clash between these two AFC squads as it goes down to the wire, with the Chiefs reigning victorious as they wrap up Week 5 with a big win on Monday Night Football.
Chiefs vs. Jaguars Betting Trends
- The Chiefs have long dominated the Jaguars head-to-head, having won eight consecutive matchups, including regular and postseason games dating back to 2010.
- In their two wins this season, the Chiefs have won both games by double digits. The current spread for Monday Night Football is -3.5.
- In the Patrick Mahomes/Trevor Lawrence eras for their respective teams the final score has resulted in over 45.5 points just once in three games.
- The Jaguars are 3-1 ATS in 2025, including a perfect 2-0 record at home.
Top Player Props to Watch on Monday Night Football
- WR Tyquan Thornton Anytime Touchdown Scorer (+325) – Three straight games with a touchdown scored.
- QB Patrick Mahomes 300+ Passing Yards (+300) – Has thrown for 300+ passing yards in all four meetings with the Jaguars in his career.
- RB Travis Etienne Anytime Touchdown Scorer (+115) – Three straight games with a touchdown scored.
- TE Brenton Strange over 33.5 Receiving Yards (-110) – Hit this mark in three of his four games played in 2025, averaged 45.5 yards per game.
Monday Night Football Injury Report
Chiefs
- WR Xavier Worthy (Questionable) – Ankle
- CB Kristian Fulton (Questionable) – Ankle
- DT Omarr Norman-Lott (Questionable – Shoulder
Jaguars
- DE Travon Walker (Questionable) – Wrist
- G Wyatt Milum (Questionable) – Knee
- LB Yasir Abdullah (OUT) – Hamstring