Opening Week 4 of the 2025 NFL season with a rivalry matchup out of the NFC West, the Seattle Seahawks will travel to Glendale to take on the Arizona Cardinals on Thursday Night Football. As both sides look to gain control over their division with a pivotal early-season clash, the only way the action could get any better is by placing a bet on the Seahawks vs. Cardinals at one of our best NFL betting sites.
Bet on Seahawks vs. Cardinals
SEA -1
ARI +1
Below, we’ve highlighted the latest Thursday Night Football odds as well as out expert picks & predictions so you can secure a massive payday on your NFL bets in Week 4. Along with our helpful betting insight, our comprehensive Thursday Night Football betting preview also features helpful trends and information to assist you in building a winning bet slip.
Don’t wait, lace up your cleats, throw on your best game face, and get ready to win big with our Seahawks vs. Cardinals betting preview.
| Seahawks Moneyline Odds | -115 |
| Cardinals Moneyline Odds | -105 |
| Spread odds | Seahawks -1 (-110), Cardinals +1 (-110) |
| Over/Under | Over 43.5 points (-110), Under 43.5 points (-110) |
| Time/Date | Sep. 25, 8:15 p.m. ET |
| TV | Broadcast: TSN/DAZN |
Betting the Seattle Seahawks (2-1 SU, 2-1 ATS, 2-1 o/u)
Off to a strong start to their 2025 campaign, the Seahawks have looked superb through the first three weeks of the NFL season. Coming off of a shellacking of the lowly New Orleans Saints in Week 3, the Seahawks continued to be a moneymaker for bettors.
Having covered the spread in their lone spot as the favourite so far this season, oddsmakers have correctly placed their faith in the Seahawks thus far. They had to learn the hard way after the Seahawks notched an underdog victory in Week 2 over the Pittsburgh Steelers. Additionally, after a low-scoring season opener with the San Francisco 49ers, the Seahawks have rattled off back-to-back matchups with the over hitting, averaging 52.5 combined points over that span.
With their new-look squad continuing to make noise, the Seahawks are trending in the right direction heading into Thursday Night Football.
Betting the Arizona Cardinals (2-1 SU, 2-1 ATS, 1-2 o/u)
Starting their season off on a high note in their own right, the Cardinals have seemingly hit their stride as a unit. After an up-and-down past few seasons, the Cardinals have looked solid in 2025 and appear like legitimate playoff hopefuls in 2025.
Coming off a heartbreaking defeat against the 49ers in Week 3, as they suffered their first defeat of the year as time expired due to a game-winning field goal, the Cardinals have still managed to be a solid team to back in 2025. Having covered the spread in their lone matchup as the underdog this season, the Cardinals are adept at keeping things competitive on the gridiron. Points have come at a premium in Cardinals games so far this season, with two of their three games having finished with less than 34 total points.
As they look to navigate through injury woes in a short week, a win here could provide a major confidence boost for the Cardinals moving forward this season.
Key Injuries
Seahawks
- CB Devon Witherspoon – Questionable
- S Julian Lover – Questionable
- S Nick Emmanwori – Questionable
- EDGE Leonard Williams – Questionable
- TE Elijah Arroyo – Questionable
- C Jalen Sundell – Questionable
- LB Boye Mafe – Questionable
- FB Robbie Ouzts – Questionable
- G Josh Jones – Questionable
Cardinals
- CB Will Johnson – Questionable
- T Paris Johnson – Questionable
- G Will Hernandez – Questionable
- LB Akeem Davis-Gaither – Questionable
- CB Darren Hall – Questionable
- C Evan Brown – Questionable
- WR Zay Jones – Questionable
- RB James Conner – OUT
Seahawks vs. Cardinals Player Prop Trends
- Emerging as a premier wide receiving threat in the NFL, Jaxon Smith-Njigba has finished all three of his games played in 2025 with over 81.5 receiving yards. Averaging 107.6 yards per game for the Seahawks thus far, he’s a great candidate to exceed his set line on primetime.
- Seemingly on a downward trend in his NFL career, Seahawks wideout Cooper Kupp has struggled against the Cardinals in recent matchups. In his last three meetings with the Cardinals, Kupp has failed to tally over 41.5 receiving yards in each game. Additionally, Kupp has only reached this mark once thus far in the 2025 season.
- Continuing to be one of the top dual-threat quarterbacks in the game, Cardinals quarterback Kyler Murray has rushed for over 26.5 yards in three straight games. Averaging 35.6 yards per game on the ground, look for Murray to scramble for ample yardage against the Seahawks.
- After a breakout season in 2024, Cardinals tight end Trey McBride hasn’t been able to replicate the same success in 2025. With his receptions line set at 6.5 catches, the under on McBride receptions is a good look as he hasn’t exceeded this mark through the first three games of the year.
Seahawks vs. Cardinals Predictions
- In a matchup that oddsmakers have pegged as a “pick’em” back the Seahawks to cover the single-point spread as favourites on Thursday Night Football. The Seahawks are easily the more explosive, versatile, and healthier team entering this marquee matchup, which will completely negate any home advantage the Cardinals may have. Without running back James Conner in the lineup, the Cardinals are going to have to rely on the shaky arm of Kyler Murray, as well as their mediocre wide receiver corps to generate offence. Look for the Seahawks to get out to an early lead and never look back as they improve to 3-1 on the season, handing the Cardinals their second consecutive loss.
- Expect a slow-paced, methodical battle between these division rivals, with under 43.5 points scored between the Seahawks and Cardinals. While the Seahawks have been no strangers to high-scoring affairs this season, look for this trend to come to an end as they take on a Cardinals team that has been excellent at preventing easy scoring drives from their opponents, ranking the fifth-least points allowed per game in the NFL this season.