After two thrilling weeks of NFL action, Week 3 is set to kick off with a battle between two divisional rivals as the Miami Dolphins travel to upstate New York to take on the Buffalo Bills.
Both squads sit on opposite sides of the spectrum through the first two weeks of play, with the Bills sporting an undefeated 2-0 record, while the Dolphins remain winless. With the Bills looking to continue their superb play, and the Dolphins hoping to finally break into the win column, why not crank up the intensity around this matchup by placing a bet on the latest Thursday Night Football odds?
Bet on Dolphins vs. Bills
MIA +11.5
BUF -11.5
Below, we’ve featured the latest NFL odds for the Dolphins vs. Bills, along with our expert picks to help boost your bankroll for this primetime clash. Along with our best bets on the Dolphins vs. Bills, we’ll also provide helpful betting trends that are sure to assist you in building a winning bet slip at any of the top NFL betting sites.
Start your NFL Week 3 bets on the right foot and throw down your first winning wager with our picks and predictions on the AFC East clash between the Dolphins vs. the Bills on Thursday Night Football.
| Dolphins Moneyline Odds | +550 |
| Bills Moneyline Odds | -800 |
| Spread odds | Bills -11.5 (-110), Dolphins +11.5 (-110) |
| Over/Under | Over 49.5 points (-110), Under 49.5 points (-110) |
| Time/Date | Sep. 18, 8:15 p.m. ET |
| TV | Broadcast: TSN/DAZN |
Betting the Miami Dolphins (0-2 SU, 0-2 ATS, 1-1 o/u)
Off to a horrid start to their 2025 campaign, the Dolphins’ late-season woes from 2024 have continued into this season. Having lost both of their initial games of the season, the Dolphins are now set for a road showdown with the juggernauts of their division, the Bills.
With quarterback Tua Tagovailoa struggling with consistency as well as turnover issues, as well as the diminished production of former All-Pro wide receiver Tyreek Hill and a once formidable Dolphins defence, things are starting to get ugly in South Beach.
As far as betting the Dolphins is concerned, if you’ve been fading them thus far, you’ve likely made bank. Not only have the Dolphins dropped both of their games played early this season, but they’ve also failed to cover the spread as underdogs in both of their matchups. Scoring numbers have also been up and down for the Fins, with no true indications on what the direction of this team is.
So far in 2025, the Dolphins have been a team to fade, something that may be a profitable look for all bettors heading into Thursday Night Football.
Betting the Buffalo Bills (2-0 SU, 2-0 ATS, 1-1 o/u)
Building off of their sensational comeback victory over the Baltimore Ravens in Week 1, the Bills continued their Super Bowl push as they beat the brakes off of the New York Jets on the road in Week 2. Putting up a dominant 20-point victory over their division rivals, the Bills are hungry to move to 2-0 in divisional play entering into Thursday Night Football.
Unlike the Dolphins, backing the Bills has been a moneymaking move early on in 2025. Good teams win, but great teams cover, and this has proven true for the Bills, who have not only won outright in both games played this season but also covered the spread in each matchup. The Bills have also been a solid scoring squad offensively, having put up 30 or more points through their first two games of the year.
With no signs of slowing down as they move into a primetime duel in front of the Bills Mafia, look for Buffalo to keep on pushing the wagon into Week 3.
Key Injuries
Heading into this short-week matchup, both sides have numerous names listed on their injury report.
For the Dolphins, they have a slew of players holding a questionable designation entering into Thursday Night Football. Key contributors such as WR Jaylen Waddle, TE Darren Waller, LB Chop Robinson, and CB Storm Duck have all been limited in practice so far this week, raising some alarm bells for Dolphins faithful as they look to avoid dropping to 0-3.
For the Bills, head coach Sean McDermott had some bad news to deliver early this week as he ruled out both DT Ed Oliver and LB Matt Milano ahead of their clash with the Dolphins. The list of injuries on the Bills’ defence doesn’t just end there, as LB Shaq Thompson and CB Taron Johnson are also both listed as questionable heading into Thursday Night Football.
Dolphins vs. Bills Player Prop Trends
- In his last seven starts against the Bills, Tua Tagovailoa has averaged 208 passing yards. With his line set at 234.5 passing yards, the under is a good look as he’s failed to exceed this mark in six of his last seven meetings against Buffalo.
- Over his last four games played against the Bills, Tyreek Hill has hauled in under 5.5 receptions in three of his last four meetings. Additionally, Hill has failed to reach this mark in four of his last six regular-season games dating back to the 2024 season.
- In 14 career games played against the Dolphins, Josh Allen has thrown for 2+ touchdowns in 13 of them. Additionally, he has had 3+ touchdown passes in seven of those games, a prop bet that would net you a +280 payday if he continues this trend in Week 3.
- Surprisingly, Bills running back James Cook has struggled to produce against the Dolphins in his career. Over his last five head-to-head games against the Fins, Cook has rushed for under 67.5 yards in four of them.
Dolphins vs. Bills Predictions
- Primed to continue their sensational start to the 2025 NFL season, bank on the Bills to take care of business against the Dolphins as they improve to 3-0 on Thursday Night Football. The Bills have dominated this matchup, having won six straight games against the Dolphins head-to-head.
- While the Bills moneyline is an excellent look, I’d be cautious when betting the spread in this contest. At a daunting 11.5 points, the Dolphins have covered this spread in five of their last seven games played. Additionally, in the six consecutive victories for the Bills over the Dolphins, there have only been two occasions where this 11.5-point spread would have been covered.
- When it comes to betting the point total, the under is the smart play for this primetime affair. While both sides have put forth strong scoring efforts when sharing the field, this clash could escalate quickly. Look for the Bills to gain control early, pounding the rock and draining the clock as they prevent their opponents from garnering any opportunities to create a comeback. The under has been the best bet for point total bettors so far this season, with 56.2% of games finishing below the projected total.