The current season marks the first appearance of Inter Miami and Nashville SC in the league. They are the 25th and 26th franchises of the Major League Soccer. In the regular season, they are divided into two conferences, and a total of fourteen make their way to the playoffs. The two best teams fight for the MLS Cup and qualify for the CONCACAF Champions' League.
Three franchises folded since the creation of the Major League Soccer. Two of them were teams from Florida. The other one was a subsidiary of the famous Chivas Guadalajara, from Mexico.
- Chivas USA
- Miami Fusion
- Tampa Bay Mutiny
Major League Soccer already confirmed the next three teams, which will debut in the league. Inter Miami and Nashville start to write their histories in 2020. Austin FC's first game is scheduled for 2021. Sacramento and St. Louis battle to become the 28th franchise and the chosen city should begin its activities in 2022.
- Austin FC
- Sacramento Republic
- St. Louis