NFL Wild Card Weekend Playoff Matchups, Opening Odds: Bills Small Road Favourites vs. Jaguars

The stage is finally set for the NFL playoffs with Wild Card Weekend set to commence on Saturday.

Exactly 14 teams are set to compete for Super Bowl glory over the next month, but only 12 will be in action this weekend after the Denver Broncos (AFC No. 1 seed) and the Seattle Seahawks (NFC No. 1 seed) earned opening-round byes. This year’s Super Bowl will be played at Levi’s Stadium in the San Francisco Bay Area on Feb. 8.

Here are the opening NFL Wild Card round odds and early line moves.

NFL matchups and odds for Wild Card Weekend

Matchup	Date/Time	Moneyline Odds	Spread	Over/Under
LA Rams @ Carolina Panthers	Saturday, Jan. 10, 4:30 p.m. ET	Rams -600, Panthers +450	Rams -10	46.5
Green Bay Packers @ Chicago Bears	Saturday, Jan. 10, 8 p.m. ET	Bears -115, Packers -105	Bears -1	46.5
Buffalo Bills @ Jacksonville Jaguars	Sunday, Jan. 11, 1 p.m. ET	Bills -120, Jaguars +100	Bills -1.5	51.5
San Francisco 49ers @ Philadelphia Eagles	Sunday, Jan. 11, 4:30 p.m. ET	Eagles -210, 49ers +175	Eagles -3.5	46.5
LA Chargers @ New England Patriots	Sunday, Jan. 11, 8 p.m. ET	Patriots -205, Chargers +170	Patriots -3.5	46.5
Houston Texans @ Pittsburgh Steelers	Monday, Jan. 12, 8:15 p.m. ET	Texans -180, Steelers +150	Texans -3	39.5

Rams @ Panthers

• Rams are the biggest favourites of the week on the moneyline (-600) and spread (-10).
• Rams opened as 10.5-point favourites at most online sportsbooks on the spread, but that has been bet down to as low as -9.5 at some books (Betway).
• The Panthers won the NFC South despite having just an 8-9 record.
• Carolina was 5-3 straight up and 5-3 against the spread at home during the regular season.

Packers @ Bears

• The two teams split their regular-season series, with the home team winning each matchup by six points or more.
• The Packers were just 6-10 ATS overall and a dreadful 2-6 ATS on the road during the regular season.
• The under was 5-2 in Chicago’s seven home games during the regular season.
• Chicago went 6-1 SU at home this season.

Bills @ Jaguars

• The Bills have qualified for the playoffs for the seventh consecutive season, but it’s the first time since 2019 Buffalo has not won the AFC East Division.
• The Jaguars enter the playoffs riding an eight-game winning streak and have allowed 20 points or less in each of those games aside from one overtime game.
• Buffalo led the league in rushing yards (2,714) during the regular season, but Jacksonville allowed the fewest rushing yards per game (85.6).
• The over was 6-2 in Jacksonville’s eight home games this season.

49ers @ Eagles

• The 49ers are ravaged by injuries enter the playoffs, missing elite edge rusher Nick Bosa and linebacker Fred Warner. Linebackers Dee Winters and Tatum Bethune both suffered injuries on Jan. 3 against the Seahawks. Quarterback Brock Purdy is also nursing a thumb injury.
• The 49ers were an impressive 7-2 ATS on the road this season.
• The Eagles have allowed just 19.1 points per game this season, the fifth-lowest total in the NFL.

Chargers @ Patriots

• The Patriots averaged an impressive 28.8 points per game during the regular season (second most in the NFL) thanks to their potent rushing attack, which averaged 128.9 yards per game (sixth most in the league).
• Patriots quarterback Drake Maye has the second shortest odds to win league MVP (+140) behind Matt Stafford (-180) after throwing for over 4,000 yards and 30 touchdowns.
• The Chargers went 5-2 SU on the road during the regular season.

Texans @ Steelers

• This will be the first time these two teams have ever met in the NFL playoffs.
• Houston’s defence ranked first in total yards allowed (298.8) and second in points allowed per game (17.4) during the regular season.
• The Texans enter the postseason on a nine-game winning streak.
• Steelers quarterback Aaron Rodgers is just 12-10 in the playoffs in his illustrious career.