Thursday Night Football Odds, Betting Preview (Sept. 11): Commanders Vs. Packers Predictions

Detroit Lions offensive tackle Penei Sewell (58) blocks Green Bay Packers defensive end Micah Parsons (1) during the second quarter of their game Sunday, September 7, 2025 at Lambeau Field in Green Bay, Wisconsin.

After an action-packed Week 1 of NFL football, Week 2 promises to bring the same level of intensity and excitement. Kicking things off with a heavyweight showdown between two of the top teams in the NFC, the Washington Commanders will head to Lambeau Field to take on the Green Bay Packers on Thursday Night Football.

With both squads having achieved impressive victories against divisional rivals to open their 2025 campaign, both sides are looking to shine bright under the lights of primetime in this marquee matchup. As we approach kick-off, the only way the Commanders vs. Packers could get any better is by placing a bet on the latest Thursday Night Football odds.

Bet on Commanders vs. Packers

WSH +3.5
GB -3.5

Below, we’ve highlighted the best Thursday Night Football odds, as well as winning betting trends, and our best bets for this colossal clash. With our expert insight and analysis, you’ll be prepared to hit paydirt on all your bets placed on the Commanders vs. Packers in Week 2.

Don’t wait, lace up those cleats, charge out of the tunnel, and get ready for a hard-hitting matchup that’ll wind up with you boosting your bankroll to kickstart your NFL Week 2 bets.

Commanders Moneyline Odds+155
Packers Moneyline Odds-185
Spread oddsPackers -3.5 (-105), Commanders +3.5 (-105)
Over/UnderOver 48 points (-110), Under 48 points (-110)
Time/DateSep. 11, 8:15 p.m. ET
TVBroadcast: TSN/DAZN

Betting the Washington Commanders (1-0 SU, 1-0 ATS, 0-1 o/u)

The darlings of the 2024 NFL season, the Commanders continued to prove that they’re one of the best young teams across the NFL with a dominant 21-8 victory over the new-look New York Giants in Week 1. With star quarterback Jayden Daniels continuing to look the part of a franchise player, as well as big contributions from new members to the roster such as wide receiver Deebo Samuel, the Commanders look like they’re ready for another run toward the NFL Playoffs.

In Week 1, the Commanders covered the spread with ease, exemplifying that good teams win, but great teams cover. The Commanders did fall under the Week 1 point-scoring dry spell that hit the majority of the league to open the season, but don’t get it twisted, they’re still capable of popping off for big-time scoring performances at any time.

Betting the Green Bay Packers ( 1-0 SU, 1-0 ATS, 0-1 o/u)

Making a major statement in their Week 1 clash with the reigning NFC North champions, the Detroit Lions, the Packers beat their bitter rivals from pillar to post to open their 2025 campaign. With franchise quarterback Jordan Love continuing to make dazzling plays, as well as the continued growth of several other young playmakers within the Packers roster, this new version of the team may be the most dangerous we’ve seen in years.

Additionally, Week 1 marked the debut of All-Pro pass-rusher Micah Parsons with the Packers, as he notched a sack in limited snaps against the Lions. With his role likely only set to increase heading into Thursday Night Football, we may only be scratching the surface of the Packers’ ultimate potential this season.

Key Injuries

Heading into Thursday Night Football, both sides have a few names listed on their current injury reports

For the Commanders, punter Tress Way, wide receiver Noah Brown, and running back Austin Ekeler are all listed as questionable for their duel with the Packers. All three players were limited participants at practice, which would indicate they’re leaning towards suiting up for action, at the very least in a reduced role.

For the Packers, they have a slew of questionable tags applied to their lineup. Notable names featured on the Packers injury report include tackle Zach Tom, wide receiver Jayden Reed, and linebackers Micah Parsons and Quay Walker. While for most teams, having this many names pop up on the injury report could be cause for panic, in the case of the Packers, they boast a tremendous amount of depth. If any of these top players are unable to suit up, they have dependable backups ready to fill their shoes.

  • Commanders quarterback Jayden Daniels has thrown for over 226.5 passing yards in six consecutive games, including both regular and postseason contests, where he played in all four quarters of the game. In those five games, he averaged 256.6 passing yards.
  • A go-to end zone target for the Commanders, tight end Zach Ertz has scored a touchdown in four of his last six games, including both regular-season and postseason contests. He’s currently priced at +240 as an anytime touchdown scorer on the latest Thursday Night Football odds.
  • Looking to extend his franchise-record touchdown streak, Packers running back Josh Jacobs has scored a tuddy in nine consecutive regular-season games. Priced at -200 as an anytime touchdown scorer, Jacobs will look to hit double digits with his scoring streak in primetime.
  • While Jordan Love has put up impressive numbers in his brief tenure as a starting quarterback, his yardage isn’t as consistent as many would like to see. Having thrown for under 234.5 passing yards in six straight games in which he’s played all four quarters, including regular season and postseason, Love may have trouble racking up completions against a solid Commanders secondary.

Commanders vs. Packers Predictions

  • In a clash between two evenly matched squads, look for the home advantage to play a significant factor in the Packers taking the victory on Thursday Night Football. Expect to see the Packers work well in the short passing attack, picking up easy yardage as they chip away downfield, forcing the Commanders to play catch-up on the other side. The Packers’ front seven is sensational this season, set to terrorize Jayden Daniels all game long and prevent their run game from ever developing. In a game that could come down to the final possession, back the Packers on the moneyline to remain undefeated through Week 2, in a potential postseason clash between two of the most promising young teams in the league.
  • While betting the under was the profitable pick in Week 1, let’s look to buck the trend as the Commanders vs. Packers results in over 48 total points. Both sides are known for their big, explosive plays downfield, resulting in points put on the board in a hurry. In their respective season-opening matchups, both the Commanders and Packers put up 21+ points, showing that their offences were clicking. Additionally, in the four primetime games played in Week 1 (including the Chargers vs. Chiefs), three of the four games hit the over. Look for the scoreboard to light up routinely in the Commanders vs Packers clash on Thursday Night Football and watch as your bankroll rises alongside the final score.