
Get ready for the final Grand Slam of the tennis season with our 2021 US Open betting preview.
The last Grand Slam of the year – the 2021 US Open – begins this week, running until September 12. The event – held annually in New York City – is one full of talented players and interesting storylines going in. Although with the intrigue, there are plenty of wagering opportunities on the event. So what are the best bets to win the 2021 US Open?
Best Picks to Win the 2021 ATP US Open
To Win the US Open | ![]() |
---|---|
Novak Djokovic | 1.63 |
Daniil Medvedev | 5.20 |
Alexander Zverev | 6.96 |
Stefanos Tsitsipas | 10.00 |
Andrey Rublev | 20.00 |
Matteo Berrettini | 36.00 |
Jannik Sinner | 38.00 |
Denis Shapovalov | 42.00 |
More players are available to bet at Sports Interaction.
With a few stars absent, most eyes going into the men’s singles tournament will focus on Novak Djokovic.
Will Novak Djokovic Sweep the Grand Slams in 2021?
While Novak Djokovic will not accomplish the Golden Slam, the world no. one still has a chance at becoming the first man ever to achieve the Calendar Grand Slam. Djokovic is the best player in the world right now – and is at his best when the lights are brightest.

The field at the tournament is also favourable for the Joker. Djokovic has five losses in the US Open Finals. Only one of the five players who beat him – Andy Murray – is in the event this year. The lack of Rafael Nadal is the biggest absence. Nadal has 28 wins against the Joker in his career – including two in the finals. Removing the five losses in the Finals gives Djokovic a 75-7 career record at the US Open.
The Joker likely would be the reigning US Open Champion if he were not forced to retire early last year due to injuries. Having taken off all events since the injuries gives his body time to rest up. The tournament’s early rounds – against the lowest-ranked players to qualify – gives him time to get up to Grand Slam playing speed.
Hate him or love him – Djokovic is the best in the world. There are so many reasons he is the favourite on tennis odds. He can handle the pressure, fight back from 0-2 deficits, and match any player’s strengths and exploit their weaknesses. Wager on him to win the 2021 US Open.
Andrey Rublev is an Underdog Worth Backing
Out of all the underdogs – which you can argue is everyone but the Joker – the best player to back, is Andrey Rublev. Rublev has played well at the US Open – making the quarterfinals twice in his career (2017 and 2020).
He is 25-7 on hard courts this season – which does not account for his Gold Medal in mixed doubles at the 2020 Summer Olympics. One of his biggest wins came at the Cincinnati Open. Rublev knocked off world no. two Daniil Medvedev (who knocked out Rublev at the 2020 US Open) to advance to the finals.
For the value and talent, plus a favourable draw – Rublev is the best underdog to bet will win the 2021 US Open.
Best Picks to Win the 2021 WTA US Open
To Win the US Open | ![]() |
---|---|
Novak Djokovic | 1.63 |
Daniil Medvedev | 5.20 |
Alexander Zverev | 6.96 |
Stefanos Tsitsipas | 10.00 |
Andrey Rublev | 20.00 |
Matteo Berrettini | 36.00 |
Jannik Sinner | 38.00 |
Denis Shapovalov | 42.00 |
More players are available to bet at Sports Interaction.
A deep field on the women’s side of the tournament makes for an exciting draw and plenty of betting opportunities.
Ashleigh Barty Enters the Tournament as the Best Bet to Win
The top-ranked woman in the world – Ashleigh Barty, opens the US Open as the favourite to win – and deservedly so. Barty is coming off an incredible win at the 2021 Cincinnati Open. She demolished the competition – not dropping a set over five rounds. She also won Wimbledon this year, losing only two sets in seven rounds.
Although Barty has not won the women’s singles US Open yet, she has made the doubles side finals twice, winning once (in 2018). She did not play at the event in 2020 – but would have been one of the best players had she participated.
Over the last two WTA seasons, she has been at her best on hard courts, owning a record of 30-6. We expect her to continue her amazing 2021 and take home the third Grand Slam of her career.
Naomi Osaka is at her Best at Arthur Ashe Stadium
The tale of Naomi Osaka this year – for lack of a better word – has been quite the rollercoaster. While her battles with mental health and the media have been at the forefront lately, we cannot forget how much of a talent the 23-year-old is.
Osaka is the reigning US Open Champion and also won in 2018. She also picked up her second victory at the Australian Open to kick off the 2021 WTA season. Osaka is 15-3 on hardcourts this season (in four tournaments).

She has the ability to beat anyone on the planet – including Ash Barty – who she is 2-2 against all-time. Two of those wins came on hard courts.
Best Online Sportsbooks to Bet on the US Open
Find the best online sportsbooks to bet on the 2021 US Open below. New users can snag an exclusive welcome bonus when they join through the links underneath, which you can use to bet on the 2021 US Open.